This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Walter E. Laug, MD

JAMA. 1983;250(6):772-776.

Abstract
Confluent cultures of cloned bovine endothelial cells, which were derived from large vessels, produced and secreted plasminogen activator (PA) at constant rates. Exposure of these cultures to increasing concentrations of ethyl alcohol resulted in a significant augmentation of PA production and secretion. This effect, which was observed after three hours and was maximal after 18 hours of incubation, was abolished by simultaneous exposure of the cultures to cycloheximide, indicating that active protein synthesis was necessary for the observed increase of PA activity. Other aliphatic alcohols such as propanol and butanol also significantly augmented PA production and secretion by endothelial cells, whereas acetaldehyde and acetylcoenzyme A, known metabolites of ethyl alcohol, had no stimulatory effect on protease secretion by the cells. Therefore, the alcohol itself rather than its metabolites was responsible for the enhancement of PA secretion by endothelial cells. These in vitro studies may explain the increased fibrinolytic activity found in the plasma of persons consuming moderate amounts of alcohol.

(JAMA 1983;250:772-776)

Author Affiliations
From the Division of Hematology-Oncology, Children's Hospital of Los Angeles, and the University of Southern California School of Medicine, Los Angeles.

Footnotes
Reprint requests to Division of Hematology-Oncology, Children's Hospital of Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027 (Dr Laug).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Impact of Clopidogrel in Patients With Acute Coronary Syndromes Requiring Coronary Artery Bypass Surgery: A Multicenter Analysis
Berger et al.
J Am Coll Cardiol 2008;52:1693-1701.
ABSTRACT | FULL TEXT  

Alcohol Consumption and Mortality From Stroke and Coronary Heart Disease Among Japanese Men and Women: The Japan Collaborative Cohort Study
Ikehara et al.
Stroke 2008;39:2936-2942.
ABSTRACT | FULL TEXT  

Alcohol Consumption and Risk of Stroke Among Middle-Aged Men: The JPHC Study Cohort I
Iso et al.
Stroke 2004;35:1124-1129.
ABSTRACT | FULL TEXT  

Relation of Drinking Alcohol to Atherosclerotic Risk in Type 2 Diabetes
Wakabayashi et al.
Diabetes Care 2002;25:1223-1228.
ABSTRACT | FULL TEXT  

Serum Gamma-Glutamyl Transferase, Self-Reported Alcohol Drinking, and the Risk of Stroke
Jousilahti et al.
Stroke 2000;31:1851-1855.
ABSTRACT | FULL TEXT  

The Effect of Acute Ingestion of a Large Dose of Alcohol on the Hemostatic System and Its Circadian Variation
Numminen et al.
Stroke 2000;31:1269-1273.
ABSTRACT | FULL TEXT  

Activation of Guanine Nucleotide-binding Proteins and Induction of Endothelial Tissue-type Plasminogen Activator Gene Transcription by Alcohol
Miyamoto et al.
J. Biol. Chem. 1999;274:12055-12060.
ABSTRACT | FULL TEXT  

State-of-the-Art Review : Sex and Cardiovascular Risk Factors
Prisco et al.
CLIN APPL THROMB HEMOST 1996;2:94-102.
 

Stroke and Alcohol Intake in a Hospital Population : A Case-Control Study
Beghi et al.
Stroke 1995;26:1691-1696.
ABSTRACT | FULL TEXT  

The Primary Prevention of Coronary Heart Disease in Women
Rich-Edwards et al.
NEJM 1995;332:1758-1766.
FULL TEXT  

Alcohol Intake and the Risk of Cardiovascular Disease in Middle-Aged Japanese Men
Iso et al.
Stroke 1995;26:767-773.
ABSTRACT | FULL TEXT  

Association of Moderate Alcohol Consumption and Plasma Concentration of Endogenous Tissue-Type Plasminogen Activator
Ridker et al.
JAMA 1994;272:929-933.
ABSTRACT  

Low Levels of High-Density Lipoprotein Cholesterol (Hypoalphalipoproteinemia) An Approach to Management
Rosenson
Arch Intern Med 1993;153:1528-1538.
ABSTRACT  

Case 27-1993- A 32-Year-Old Man with the Sudden Onset of a Right-Sided Headache and Left Hemiplagia and Hemianesthesia
Tapia and Schumacher
NEJM 1993;329:117-124.
FULL TEXT  

Alcohol and the Heart: The Long-term Effects of Alcohol on the Cardiovascular System
Moushmoush and Abi-Mansour
Arch Intern Med 1991;151:36-42.
ABSTRACT