Amoxapine overdose. Seizures and fatalities
T. L. Litovitz and W. G. Troutman
Thirty-three amoxapine overdoses, including five fatalities, were reported
to two regional poison centers over an 18-month study period. The 15.2%
mortality rate stands in alarming contrast to the 0.7% death rate for all
other cyclic antidepressant overdoses reported to these same two centers
during the study. Seizure activity was noted in 36.4% of amoxapine
overdoses, compared with 4.3% of other cyclic antidepressant poisonings.
Amoxapine appears to be responsible for a disproportionate share of
seizures and deaths resulting from cyclic antidepressant overdose.
