B-cell immunodeficiency in acquired immune deficiency syndrome

A. J. Ammann, G. Schiffman, D. Abrams, P. Volberding, J. Ziegler and M. Conant

To investigate B-cell function in acquired immune deficiency syndrome (AIDS), we immunized a group of patients with AIDS with pneumococcal polysaccharide (tetradecavalent) and protein (keyhole-limpet hemocyanin) antigens. Antibody responses were determined three to four weeks after immunization. Compared with controls, patients with AIDS had significantly lower geometric mean antibody levels to polysaccharide before and after immunization. Levels before and after immunization were frequently below a level thought to correlate with protection. Patients with AIDS also had a significant reduction in their primary antibody response to the protein antigens. The results of these studies indicate that AIDS is associated with an acquired B-cell as well as T-cell immunodeficiency. It is suggested that future studies should consider the evaluation of passive antibody in the prevention of infection and/or prevention of progressive immunodeficiency.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Trends in Bacteremia in the Pre- and Post-Highly Active Antiretroviral Therapy Era Among HIV-Infected Children in the US Perinatal AIDS Collaborative Transmission Study (1986-2004)
Kapogiannis et al.
Pediatrics 2008;121:e1229-e1239.
ABSTRACT | FULL TEXT  

Local and Systemic Effects of Intranodally Injected CpG-C Immunostimulatory-Oligodeoxyribonucleotides in Macaques
Teleshova et al.
J. Immunol. 2006;177:8531-8541.
ABSTRACT | FULL TEXT  

Combination Exposure to Zidovudine plus Sulfamethoxazole-Trimethoprim Diminishes B-Lymphocyte Immune Responses to Pneumocystis murina Infection in Healthy Mice
Feola and Garvy
CVI 2006;13:193-201.
ABSTRACT | FULL TEXT  

CpG-C ISS-ODN activation of blood-derived B cells from healthy and chronic immunodeficiency virus-infected macaques
Teleshova et al.
J. Leukoc. Biol. 2006;79:257-267.
ABSTRACT | FULL TEXT  

HIV Impairs TNF-{alpha} Release in Response to Toll-Like Receptor 4 Stimulation in Human Macrophages In Vitro
Tachado et al.
Am. J. Respir. Cell Mol. Bio. 2005;33:610-621.
ABSTRACT | FULL TEXT  

Persistence of HIV-1 structural proteins and glycoproteins in lymph nodes of patients under highly active antiretroviral therapy
Popovic et al.
Proc. Natl. Acad. Sci. USA 2005;102:14807-14812.
ABSTRACT | FULL TEXT  

Abnormal CD40 Ligand (CD154) Expression in Human Immunodeficiency Virus-Infected Children
O'Gorman et al.
CVI 2001;8:1104-1109.
ABSTRACT | FULL TEXT  

Bacterial Pneumonia in Hospitalized Patients With HIV Infection: The Pulmonary Complications, ICU Support, and Prognostic Factors of Hospitalized Patients With HIV (PIP) Study
Afessa and Green
Chest 2000;117:1017-1022.
ABSTRACT | FULL TEXT  

Protective Immunity of Microsphere-Based Mucosal Vaccines against Lethal Intranasal Challenge with Streptococcus pneumoniae
Seong et al.
Infect. Immun. 1999;67:3587-3592.
ABSTRACT | FULL TEXT  

Possible Role of Interleukin-10 (IL-10) and CD40 Ligand Expression in the Pathogenesis of Hypergammaglobulinemia in Human Immunodeficiency Virus Infection: Modulation of IL-10 and Ig Production After Intravenous Ig Infusion
Muller et al.
Blood 1998;92:3721-3729.
ABSTRACT | FULL TEXT  

Use of Licensed Vaccines for Active Immunization of the Immunocompromised Host
Pirofski and Casadevall
Clin. Microbiol. Rev. 1998;11:1-26.
ABSTRACT | FULL TEXT  

Bacterial Pneumonia in Persons Infected with the Human Immunodeficiency Virus
Hirschtick et al.
NEJM 1995;333:845-851.
ABSTRACT | FULL TEXT  

Should patients positive for HIV infection receive pneumococcal vaccine?
Jain et al.
BMJ 1995;310:1060-1062.
FULL TEXT  

A Controlled Trial of Intravenous Immune Globulin for the Prevention of Serious Bacterial Infections in Children Receiving Zidovudine for Advanced Human Immunodeficiency Virus Infection
Spector et al.
NEJM 1994;331:1181-1187.
ABSTRACT | FULL TEXT  

HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals
Moir et al.
Proc. Natl. Acad. Sci. USA 2001;98:10362-10367.
ABSTRACT | FULL TEXT