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Arthur J. Ammann, MD; Gerald Schiffman, PhD; Donald Abrams, MD; Paul Volberding, MD; John Ziegler, MD; Marcus Conant, MD

JAMA. 1984;251(11):1447-1449.

Abstract
To investigate B-cell function in acquired immune deficiency syndrome (AIDS), we immunized a group of patients with AIDS with pneumococcal polysaccharide (tetradecavalent) and protein (keyhole-limpet hemocyanin) antigens. Antibody responses were determined three to four weeks after immunization. Compared with controls, patients with AIDS had significantly lower geometric mean antibody levels to polysaccharide before and after immunization. Levels before and after immunization were frequently below a level thought to correlate with protection. Patients with AIDS also had a significant reduction in their primary antibody response to the protein antigens. The results of these studies indicate that AIDS is associated with an acquired B-cell as well as T-cell immunodeficiency. It is suggested that future studies should consider the evaluation of passive antibody in the prevention of infection and/or prevention of progressive immunodeficiency.

(JAMA 1984;251:1447-1449)

Author Affiliations
From the Departments of Pediatrics (Dr Ammann), Internal Medicine (Drs Abrams and Volberding), and Dermatology (Dr Conant), University of California, San Francisco Medical Center; the Department of Internal Medicine, Veterans Administration Hospital, San Francisco (Dr Ziegler); and the Department of Microbiology, State University of New York, Down-state Medical Center, Brooklyn, NY (Dr Schiffman).

Footnotes
Reprint requests to Department of Pediatrics, M-679, University of California, San Francisco Medical Center, San Francisco, CA 94143 (Dr Ammann).

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