Cutaneous allergy to human (recombinant DNA) insulin
L. C. Grammer, B. E. Metzger and R. Patterson
p6 report two cases of cutaneous allergy to human (recombinant DNA)
insulin. Each patient had a history of systemic allergic reactions to
porcine insulin and was at least as reactive to human as to porcine insulin
by end-point cutaneous titration. Both patients' insulin allergy was
managed with animal insulins and both have done well. Our experience with
these two patients indicates that human insulin (rDNA) should not be
expected to be efficacious in all patients with systemic allergy to
insulin.
