Parenteral fat emulsions and immune adherence. The effects of triglycerides on red cell and neutrophil immune adherence in vitro and in vivo
I. Siegel, T. L. Liu, P. Zaret and N. Gleicher
Parenteral fat emulsions may not only exert nutritional effects but may
also affect immune adherence phenomena and red cell morphology. Red cell
immune adherence (RCIA) was augmented in vitro by 0.05% to 0.1% Intralipid.
Similar augmentation of RCIA was observed by peanut oil, corn oil,
half-and-half cream, paraffin oil, and human low-density lipoprotein
fractions. Neutrophil immune adherence was augmented in vitro by 0.2% to
1.5% of Intralipid. The effects of fat emulsions in vivo were studied in
ten patients who received intralipid for nutritional purposes. Red cell
immune adherence was augmented in five of ten patients and inhibited in
four of ten patients. Neutrophil immune adherence was augmented in two of
ten patients. Cytotoxic red cell transformations were evident in five of
ten patients. Depression of RCIA in four of five patients was associated
with cytotoxic red cell transformations.
