The relation of cytomegalovirus and Epstein-Barr virus antibodies to T-cell subsets in homosexually active men
R. Detels, B. R. Visscher, J. L. Fahey, K. Schwartz, R. S. Greene, D. L. Madden, J. L. Sever and M. S. Gottlieb
Eighty-nine homosexual men participated in a study of sexual practices,
T-cell subsets, and antibody titers to cytomegalovirus (CMV) and
Epstein-Barr virus (EBV). The prevalence of antibody to CMV was 96% and to
EBV, 94%. Titers to CMV were higher in those practicing receptive anal
intercourse. The CMV antibody titers were positively correlated with the
T-helper/suppressor ratio, number of partners and venereal disease
episodes, number of T-suppressor cells, and EBV titers. Twelve percent of
the participants had a low ratio only, 18% T-suppressor augmentation, and
3% T-helper deficiency. The CMV titer and prevalence of receptive anal
intercourse were higher in those with a low ratio only, T-suppressor
augmentation, and T-helper deficiency. These results suggest that CMV
infection is acquired through receptive anal intercourse and is associated
with an increase in T-suppressor cells and, in some persons, a decrease in
T-helper cells.
