Imipramine treatment of painful diabetic neuropathy

B. Kvinesdal, J. Molin, A. Froland and L. F. Gram

Twelve patients with severe, painful diabetic neuropathy in the lower extremities were treated with imipramine and placebo in a fixed-dose, double-blind, crossover study of five plus five weeks. Seven patients experienced notable improvement while receiving imipramine and none while receiving placebo. The rating of specific symptoms at the end of each treatment period showed a beneficial effect of imipramine on pain, paresthesia, dysesthesia, numbness, and nocturnal aggravation. The plasma levels of imipramine and its metabolite desipramine were significantly higher in patients who benefited from imipramine treatment.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Painful Diabetic Peripheral Neuropathy
Smith
J. Am. Podiatr. Med. Assoc. 2007;97:394-401.
ABSTRACT | FULL TEXT  

Painful Diabetic Neuropathy: A Management-Centered Review
Huizinga and Peltier
Clin. Diabetes 2007;25:6-15.
ABSTRACT | FULL TEXT  

A randomized controlled trial of duloxetine in diabetic peripheral neuropathic pain
Wernicke et al.
Neurology 2006;67:1411-1420.
ABSTRACT | FULL TEXT  

Placebo response in clinical trials of depression and its implications for research on chronic neuropathic pain
Dworkin et al.
Neurology 2005;65:S7-S19.
ABSTRACT | FULL TEXT  

Controlled-release oxycodone for pain in diabetic neuropathy: A randomized controlled trial
Gimbel et al.
Neurology 2003;60:927-934.
ABSTRACT | FULL TEXT  

Double-blind, randomized trial of bupropion SR for the treatment of neuropathic pain
Semenchuk et al.
Neurology 2001;57:1583-1588.
ABSTRACT | FULL TEXT  

Pharmacologic treatment of pain in polyneuropathy
Sindrup and Jensen
Neurology 2000;55:915-920.
ABSTRACT | FULL TEXT  

Imipramine decreases oesophageal pain perception in human male volunteers
Peghini et al.
Gut 1998;42:807-813.
ABSTRACT | FULL TEXT  

Imipramine in Patients with Chest Pain Despite Normal Coronary Angiograms
Cannon et al.
NEJM 1994;330:1411-1417.
ABSTRACT | FULL TEXT  

Pentoxifylline in the Treatment of Distal Diabetic Neuropathy
Cohen and Mathews
ANGIOLOGY 1991;42:741-746.
ABSTRACT  

Depression and Diabetic Neuropathy: A Complex Relationship
Geringer et al.
J Geriatr Psychiatry Neurol 1988;1:11-15.
ABSTRACT