Renal thromboxane synthesis in excised kidney distal to renovascular lesions
C. B. Anderson, J. S. Tannenbaum, G. A. Sicard and E. E. Etheredge
Excision of a kidney with three distinct zones of perfusion was required in
a patient with renovascular hypertension. One third of the kidney was
normal, one third was ischemic from a stenotic artery, and one third was
severely ischemic from a completely occluded artery. This provided a unique
opportunity to study renal prostaglandin production in hypoperfused and
control tissue by radioimmunoassays of incubated tissue slices. The
thromboxane-prostacyclin synthesis ratio for the outer cortex increased
from 2.2 in control tissue to 5.8 in moderately ischemic tissue and 11.3 in
severely ischemic tissue; for the inner cortex, 2.1 to 6.3 and 8.8; and for
the medulla, 0.4 to 1.2 and 3.0, respectively . Similar ratios were noted
for thromboxane-prostaglandin E2. This correlates, for the first time in
man, absolute and relative increases in renal thromboxane synthesis with
renovascular hypertension.
