The isotretinoin teratogen syndrome
P. J. Benke
Two infants with prominent frontal bossing, hydrocephalus, microphthalmia,
and small, malformed, low-set, undifferentiated ears were born to mothers
who had taken isotretinoin in the first trimester of pregnancy. A
Dandy-Walker malformation, microcephaly, hypertelorism, small ear canals,
cleft palate, small mouth, and congenital heart disease were also observed.
Isotretinoin is a potent teratogen in man; maternal ingestion early in
pregnancy leads to a distinct clinical pattern of anomalies.
