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Gerald V. Quinnan, Jr, MD; Henry Masur, MD; Alain H. Rook, MD; Gary Armstrong; Winston R. Frederick, MD; Jay Epstein, MD; Jody F. Manischewitz, MS; Abe M. Macher, MD; Lozannie Jackson; John Ames; Holly A. Smith; Margaret Parker, MD; Gary R. Pearson, PhD; Joseph Parrillo, MD; Charles Mitchell, MD; Stephen E. Straus, MD

JAMA. 1984;252(1):72-77.

Abstract
Herpesvirus infections were studied in persons with or at risk for the acquired immune deficiency syndrome (AIDS). The infections diagnosed were as follows: patients with AIDS, cytomegalovirus (CMV) in 34 of 34, Epstein-Barr virus (EBV) in 33 of 34, herpes simplex viruses (HSV) in eight of 34, and varicella zoster virus in four of 34; patients with chronic lymphadenopathy syndrome, CMV in eight of nine and EBV in nine of nine; in healthy homosexual men, CMV in five of 13 and EBV in seven of eight. Cytomegalovirus infections were frequently related to disease and death. Herpesvirus infections are frequent causes of serious diseases in AIDS. The prevalence of EBV and CMV infections in AIDS and the chronic lymphadenopathy syndrome may be the result of an important interaction between these viruses and the cause of AIDS.

(JAMA 1984;252:72-77)

Author Affiliations
From the Division of Virology, Office of Biologics Research and Review, Center for Drugs and Biologics, Food and Drug Administration, (Drs Quinnan, Rook, Frederick, Epstein, and Mitchell, Mr Armstrong, Mr Manischewitz, and Ms Jackson); the Critical Care Medicine Department and Clinical Pathology Department, Clinical Center, National Institutes of Health, (Drs Masur, Parker, and Parrillo and Mr Ames); the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health (Dr Straus and Ms Smith); Bethesda, Md; and the Mayo Clinic, Rochester, Minn (Dr Pearson).

Footnotes
Reprint requests to Bldg 29A, HFN-840, 8800 Rockville Pike, Bethesda, MD 20205 (Dr Quinnan).

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