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Victor Froelicher, MD; David Jensen, MS; Fredric Genter, PhD; Michael Sullivan, MA; M. Dan McKirnan, PhD; Kathryn Witztum, MD; Julie Scharf; Mary Lou Strong, MA; William Ashburn, MD

JAMA. 1984;252(10):1291-1297.

Abstract
In order to determine whether or not regular exercise could alter myocardial perfusion or function, we randomized 146 male volunteers with stable coronary heart disease to either a supervised exercise program (n=72) or to a usual care program (n=74). Subjects underwent exercise tests initially and one year later. Significant differences between the two groups included improved aerobic capacity, thallium ischemia scores, and ventricular function in the exercise intervention group. It was not possible to classify the conditions of patients as to the likelihood of improvement or deterioration. This study demonstrated changes in myocardial perfusion and function in a select group of middle-aged men with coronary heart disease who underwent a medically appropriate exercise program lasting one year, but these changes were relatively modest.

(JAMA 1984;252:1291-1297)

Author Affiliations
From the Divisions of Cardiology and Nuclear Medicine, University of California School of Medicine, San Diego.

Footnotes
Reprint requests to Long Beach VA Medical Center (111 C), Cardiology Section Chief, 5901 E Seventh St, Long Beach, CA 90822 (Dr Froelicher).

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