Death caused by recreational cocaine use. An update
R. E. Mittleman and C. V. Wetli
The epidemiologic, pathological, and toxicological findings of 60
cocaine-related overdose deaths from middle 1978 through 1982 were studied
and compared with a previous publication by this office. In addition, 180
deaths where cocaine was an incidental toxicological finding are also
discussed. Currently, the average street cocaine fatality victim is 29
years old, and 42% of the victims are female. Blacks comprise 39% of the
cases. The blood cocaine concentration in "street cocaine" fatality victims
averaged 6.2 mg/L with a wide range, necessitating careful interpretation
of the toxicological results in conjunction with terminal events. Although
autopsy findings were generally nonspecific, multiple needle-puncture marks
with surrounding ecchymoses are typical of IV cocaine abuse. An increase in
cocaine-related overdose deaths is anticipated because of its popularity,
increasing availability, and, currently, the increased purity of street
cocaine.
Molecular Determinants of Cocaine Block of Human Ether-a-go-go-Related Gene Potassium Channels
Guo et al.
J. Pharmacol. Exp. Ther. 2006;317:865-874.
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Effects of Cocaine and Its Major Metabolites on the HERG-Encoded Potassium Channel
Ferreira et al.
J. Pharmacol. Exp. Ther. 2001;299:220-226.
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Cocaine Blocks HERG, but Not KvLQT1+minK, Potassium Channels
Zhang et al.
Mol. Pharmacol. 2001;59:1069-1076.
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Inhibition of Human Ether-A-Go-Go Potassium Channels by Cocaine
O'Leary
Mol. Pharmacol. 2001;59:269-277.
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Cocaine Increases the Endothelial Release of Immunoreactive Endothelin and Its Concentrations in Human Plasma and Urine : Reversal by Coincubation With {sigma}-Receptor Antagonists
Wilbert-Lampen et al.
Circulation 1998;98:385-390.
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Cocaine Blockade of the Acetylcholine-Activated Muscarinic K+ Channel in Ferret Cardiac Myocytes
Xiao and Morgan
J. Pharmacol. Exp. Ther. 1998;284:10-18.
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Adaptive Increase in D3 Dopamine Receptors in the Brain Reward Circuits of Human Cocaine Fatalities
Staley and Mash
J. Neurosci. 1996;16:6100-6106.
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