This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Michael Lange, MD; Elena B. Klein, MD; Hardy Kornfield, MD; Louis Z. Cooper, MD; Michael H. Grieco, MD

JAMA. 1984;252(14):1908-1910.

Abstract
The acquired immune deficiency syndrome (AIDS) has focused renewed interest on cytomegalovirus (CMV) both as an infectious complication of the syndrome and as a potential etiologic agent in the pathogenesis of the immunosuppression. We studied 30 healthy homosexual men in New York City to determine the prevalence of virus excretion and its relationship to CMV-IgM antibodies and to T-lymphocyte subsets. Cytomegalovirus was detected in the urine and/or semen of 11 subjects. Eight of 11 CMV shedders were CMV-IgM positive, but CMV IgM was found in only one of 19 not shedding the virus. While homosexuals as a group had lower 0KT4/0KT8 ratios (0.8 ±0.4, mean±SD) than heterosexual controls (1.8 ±0.4, mean ± SD), there was no significant difference in ratios between homosexuals excreting virus and those not excreting virus. Cytomegalovirus excretion by homosexual men seems to be more prevalent than previously appreciated and may pose a significant risk for sexual transmission.

(JAMA 1984;252:1908-1910)

Author Affiliations
From the Division of Infectious Diseases and Epidemiology (Drs Lange and Grieco), the Medical Service (Dr Kornfeld), and the Virology Research Laboratory and Pediatrics Service (Drs Klein and Cooper), St Luke's-Roosevelt Hospital Center, New York; and the Departments of Medicine (Drs Lange and Grieco) and Pediatrics (Drs Klein and Cooper), Columbia University College of Physicians and Surgeons, New York.

Footnotes
Reprint requests to Division of Infectious Diseases and Epidemiology, St Luke's-Roosevelt Hospital Center, Amsterdam Avenue at 114th Street, New York, NY 10025 (Dr Lange).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Viruses in the Mammalian Male Genital Tract and Their Effects on the Reproductive System
Dejucq and Jegou
Microbiol. Mol. Biol. Rev. 2001;65:208-231.
ABSTRACT | FULL TEXT  

Disseminated CMV Infection
Kotler et al.
JAMA 1985;253:3093-3094.
ABSTRACT