Transient glomerular proteinuria, enzymuria, and nephrotoxic reaction induced by radiocontrast media
G. S. Nicot, L. J. Merle, J. P. Charmes, J. P. Valette, Y. D. Nouaille, G. F. Lachatre and C. Leroux-Robert
Contrast nephropathy is a recognized complication of arteriographic
procedures; usually, it consists of a mild deterioration of renal function.
In an attempt to understand better the mechanisms involved, we conducted a
prospective study before and after arteriography that monitored the urinary
elimination of high- and low-molecular weight proteins, the urinary
activity of tubular enzymes, and renal clearances of 27 patients. We
detected a noticeable and transient nonselective proteinuria of glomerular
origin together with moderate signs of tubular damage and a stable renal
function. We did not identify any risk factor. Contrast media may alter the
disposition of charges along the glomerular filtering membrane in a way
that promotes proteinuria; consequently, the massive flow of proteins may
injure the tubular cells.
