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Stephen F. Crouse, PhD; Philip L. Hooper, MD; Hemming A. Atterbom, PhD; Richard L. Papenfuss, PhD

JAMA. 1984;252(6):785-787.

Abstract
The finding that high doses (160 mg) of zinc lowered high-density lipoprotein-cholesterol prompted us to study the effect of low-dose zinc supplementation on lipoprotein values in sedentary and endurance-trained men. Twenty-one endurance-trained and 23 sedentary men received either placebo or 50 mg of zinc sulfate daily for eight weeks. Despite the fact that plasma zinc increased 15%, fasting plasma high-density-lipoprotein cholesterol, total cholesterol, low-density-lipoprotein cholesterol, and triglyceride levels did not change in response to zinc ingestion. We conclude that low-dose zinc supplementation does not affect lipid or lipoprotein values in either endurance-trained or sedentary men.

(JAMA 1984;252:785-787)

Author Affiliations
From the Department of Health, Physical Education, and Recreation, University of New Mexico (Drs Crouse, Atterbom, and Papenfuss), and the Research Department Veterans Administration Hospital (Dr Hooper), Albuquerque. Dr Hooper is now with Consultants in Internal Medicine, PC, Loveland, Colo.

Footnotes
Reprint requests to Department of Health and Physical Education, Texas A&M University, College Station, TX 77843 (Dr Crouse).

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