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Franklyn N. Judson, MD; Josephine M. Ehret; H. Hunter Handsfield, MD

JAMA. 1985;253(10):1417-1419.

Abstract
Of the currently recommended regimens for treatment of uncomplicated gonorrhea, only aqueous penicillin G procaine is effective against infections at all sites. However, procaine penicillin is not effective against penicillinase-producing Neisseria gonorrhoeae and suffers from poor patient acceptability owing to the 10-mL volume of injection and allergic and toxic procaine reactions. Ceftriaxone is a new extended-spectrum cephalosporin with a long serum half-life and is many times more active than penicillin G against both β-lactamase—positive or —negative strains of N gonorrhoeae. Ceftriaxone was compared as a single, 125-mg, 0.5-mL injection with a single 2-g injection of spectinomycin in difficult to treat pharyngeal gonorrhea in men and women and anorectal gonorrhea of men. Ceftriaxone cured 30/32 (94%) pharyngeal and 52/52 anorectal infections, compared with 6/14 (43%) and 9/9, respectively, for spectinomycin. Both regimens were well tolerated. Ceftriaxone may prove to be a drug of choice for uncomplicated gonorrhea, particularly where homosexual men are treated and/or penicillinase-producing N gonorrhoeae is prevalent.

(JAMA 1985;253:1417-1419)

Author Affiliations
From the Disease Control Service, Denver Department of Health and Hospitals (Dr Judson and Ms Ehret), the Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center (Dr Judson), Denver; the Seattle-King County Department of Public Health, and the Department of Medicine, University of Washington School of Medicine, Seattle (Dr Hands-field).

Footnotes
Reprint requests to Disease Control Service, 605 Bannock St, Denver, CO 80204-4507 (Dr Judson).

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