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R. Philip Eaton, MD; Wilmer L. Sibbitt, Jr, MD; Alice Harsh, RN

JAMA. 1985;253(10):1437-1440.

Abstract
Improvement in range of motion and in strength of digital flexion and extension is reported in three diabetic subjects with the syndrome of limited joint mobility. Therapy was accomplished with sorbinil, an inhibitor of the enzyme aldose reductase, which inhibits the polyol pathway. We propose that reduction in collagen hydration secondary to reduced tissue content of polyols may participate in the clinical response.

(JAMA 1985;253:1437-1440)

Author Affiliations
From the Divisions of Endocrinology and Metabolism (Dr Eaton and Ms Harsh) and Rheumatology (Dr Sibbitt), Department of Medicine, University of New Mexico School of Medicine, Albuquerque.

Footnotes
Reprint requests to 2211 Lomas NE, Albuquerque, NM 87106 (Dr Eaton).

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Sorbinil and Limited Joint Mobility in Diabetics
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JAMA 1985;254:1452-1452.
ABSTRACT