The effect of an aldose reductase inhibiting agent on limited joint mobility in diabetic patients
R. P. Eaton, W. L. Sibbitt Jr and A. Harsh
Improvement in range of motion and in strength of digital flexion and
extension is reported in three diabetic subjects with the syndrome of
limited joint mobility. Therapy was accomplished with sorbinil, an
inhibitor of the enzyme aldose reductase, which inhibits the polyol
pathway. We propose that reduction in collagen hydration secondary to
reduced tissue content of polyols may participate in the clinical response.