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Assessment of Double-blindness at the Conclusion of the β-Blocker Heart Attack Trial
Robert P. Byington, PhD;
J. David Curb, MD, MPH;
Margaret E. Mattson, PhD
JAMA. 1985;253(12):1733-1736.
Abstract
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At the conclusion of a double-blinded, randomized clinical trial of propranolol hydrochloride, but before unblinding, the patients and clinic personnel were asked to guess the treatment group assignment of each patient. While 79.9% of the patients receiving propranolol correctly identified their treatment group assignment, 57.2% of the patients receiving placebo incorrectly guessed that they were also in the propranolol group. No specific mechanism was identified to explain why more patients receiving propranolol were better able to guess their group assignment. Clinic physicians correctly identified the group assignment of 69.9% of the patients receiving propranolol and 68.8% of the patients receiving placebo. Clinic coordinators correctly identified the group assignment of 67.1% of the patients receiving propranolol and 70.6% of the patients receiving placebo. For clinic personnel, heart rate level and heart rate change seem to be the mechanisms employed to identify their patients' treatment assignment.
(JAMA 1985;253:1733-1736)
Author Affiliations
β-Blocker Heart Attack Trial Research Group
From The University of Texas School of Public Health, Houston (Dr Byington); The School of Public Health and School of Medicine, University of Hawaii at Manoa, Honolulu (Dr Curb); and Division of Cancer Prevention and Control, the National Cancer Institute, Bethesda, Md (Dr Mattson).
Footnotes
Reprint requests to The University of Texas School of Public Health, Coordinating Center for Clinical Trials, Inter First Bank Bldg, Suite 1500, 1020 Holcombe Blvd, Houston, TX 77030 (Dr Byington).
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