 |
|
Albendazole—Objective Evidence of Response in Human Hydatid Disease
David L. Morris, MD;
Peter W. Dykes, MD;
Susan Marriner, PhD;
James Bogan, PhD;
Fred Burrows, FRCR;
Hilary Skeene-Smith, FRCR;
Michael J. Clarkson, MRCVS
JAMA. 1985;253(14):2053-2057.
Abstract
Thirty-two patients with cysts caused by Echinococcus granulosus were treated with albendazole in a dosage of 10 mg/kg/day. Reversible abnormalities in liver-cell function tests were seen in five patients. Some radiological evidence of remission (on serial computed tomographic or ultrasound scanning) was seen in 15 of 22 patients undergoing a therapeutic course of albendazole (as opposed to those treated before or after surgery). In five patients, the cysts virtually disappeared. Apart from reduction in size, the appearance of a halo around the cysts and the apparent disappearance of daughter cysts has been seen. Serological findings have not correlated well with radiological or clinical improvement. Serum and cyst concentrations of albendazole sulfoxide (the principal metabolite) have been measured.
(JAMA 1985;253:2053-2057)
Author Affiliations
From the Department of Surgery, University Hospital, Nottingham, England (Dr Morris), the Department of Gastroenterology, General Hospital (Dr Dykes), and the Department of Radiology (Drs Burrows and Skeene-Smith), United Birmingham Hospitals, Birmingham, England; the Department of Veterinary Pharmacology, University of Glasgow, Scotland (Drs Marriner and Bogan); and the Department of Veterinary Preventive Medicine, University of Liverpool, England (Dr Clarkson).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Extraspinal Bone Hydatidosis
Herrera and Martinez
JBJS 2003;85:1790-1794.
ABSTRACT
| FULL TEXT
Complications of albendazole treatment in hydatid disease of lung
Kurkcuoglu et al.
Eur. J. Cardiothorac. Surg. 2002;22:649-650.
ABSTRACT
| FULL TEXT
Surgical Treatment of Echinococcal Cysts of the Heart: Report of 3 Cases
Ozyazicioglu et al.
Asian Cardiovasc. Thorac. Ann. 2002;10:66-68.
ABSTRACT
| FULL TEXT
Giant hydatid lung cysts
Karaoglanoglu et al.
Eur. J. Cardiothorac. Surg. 2001;19:914-917.
ABSTRACT
| FULL TEXT
Cardiac and pericardiac echinococcosis
Kocak and Becit
Ann. Thorac. Surg. 2000;70:1002-1003.
FULL TEXT
A clinical dilemma: cardiac and pericardiac echinococcosis
Birincioglu et al.
Ann. Thorac. Surg. 1999;68:1290-1294.
ABSTRACT
| FULL TEXT
Percutaneous Drainage Compared with Surgery for Hepatic Hydatid Cysts
Khuroo et al.
NEJM 1997;337:881-887.
ABSTRACT
| FULL TEXT
False Hydatic Aneurysm of the Thoracic Aorta
Biglioli et al.
Ann. Thorac. Surg. 1995;59:524-525.
ABSTRACT
| FULL TEXT
Effective Medical Treatment for Hydatid Disease?
Schantz
JAMA 1985;253:2095-2097.
ABSTRACT
|
