This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Carol O. Tacket, MD; Lee B. Dominguez; Helaine J. Fisher; Mitchell L. Cohen, MD

JAMA. 1985;253(14):2058-2060.

Abstract
In early 1983, an outbreak of illness caused by raw milk contaminated with multiple-antimicrobial-resistant Salmonella typhimurium occurred in Arizona. One of the cases involved a 72-year-old woman who died with Salmonella enteritis and sepsis that had not responded to treatment with chloramphenicol. The S typhimurium isolates from this patient, from other ill persons, and from raw milk were resistant to ampicillin, chloramphenicol, kanamycin sulfate, streptomycin, sulfonamide, and tetracycline. These resistances were mediated by a 105-megadalton R plasmid. During the epidemic period, 43% of the S typhimurium isolates submitted to the Arizona Department of Health Services were resistant to chloramphenicol, and 80% of these possessed the same plasmid resistance. Although there was evidence of spread of the S typhimurium in the community, there was no evidence of spread of this Salmonella R plasmid to the normal flora of patients or their family members a median of 14 weeks after the infection. This outbreak demonstrates the ability of drug-resistant Salmonella to spread from the animal to the human reservoir and, in a suitable host, produce a fatal infection.

(JAMA 1985;253:2058-2060)

Author Affiliations
From the Enteric Diseases Branch, Centers for Disease Control, Atlanta (Drs Tacket and Cohen), and the Arizona Department of Health Services, Phoenix (Mr Dominguez and Ms Fisher).

Footnotes
Reprint requests to Enteric Diseases Branch, Centers for Disease Control, Bldg 1, Room 5428, 1600 Clifton Rd NE, Atlanta, GA 30333 (Dr Tacket).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Campylobacter Enteritis Outbreaks Associated With Drinking Raw Milk During Youth Activities: A 10-Year Review of Outbreaks in the United States
Wood et al.
JAMA 1992;268:3228-3230.
ABSTRACT  

Massive Outbreak of Antimicrobial-Resistant Salmonellosis Traced to Pasteurized Milk
Ryan et al.
JAMA 1987;258:3269-3274.
ABSTRACT  

Changes in Antimicrobial Resistance of Salmonella Isolated From Humans in the United States
MacDonald et al.
JAMA 1987;258:1496-1499.
ABSTRACT