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Donna Day Baird, MPH, PhD; Allen J. Wilcox, MD, PhD

JAMA. 1985;253(20):2979-2983.

Abstract
We conducted an epidemiologic study to test the hypothesis that women who smoke have reduced fertility. Data on smoking history and number of noncontracepting cycles until conception were collected from 678 pregnant women. Thirty-eight percent of nonsmokers conceived in their first cycle compared with 28% of smokers. Smokers were 3.4 times more likely to have taken greater than a year to conceive compared with nonsmokers. After adjusting for potential confounding variables by Cox proportional hazards regression, fertility of smokers was estimated to be 72% of the fertility of nonsmokers. Heavy smokers experienced lower fertility than did light smokers (57% and 75% of the pregnancy rate of nonsmokers, respectively). Fertility was not affected by the husband's smoking. These data provide evidence that reduced fertility should be added to the growing list of reproductive hazards of cigarette smoking.

(JAMA 1985;253:2979-2983)

Author Affiliations
From the Epidemiology Branch, Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC.

Footnotes
Reprint requests to Epidemiology Branch, Mail Drop A3-02, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709 (Dr Baird).

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