You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT JAMA
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 253 No. 9, March 1, 1985 TABLE OF CONTENTS
  JAMA
  •  Online Features
  ORIGINAL CONTRIBUTIONS
 This Article
 •References
 •Full text PDF
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citing articles on HighWire
 •Citing articles on Web of Science (43)
 •Contact me when this article is cited
 Related Content
 •Similar articles in JAMA
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati Add to Twitter What's this?

Hematologic Management of Hemophilia A for Surgery

Carol K. Kasper, MD; A. Lois Boylen, MD; Nadia P. Ewing, MD; James V. Luck, Jr, MD; Shelby L. Dietrich, MD

JAMA. 1985;253(9):1279-1283.


Abstract

From mid-1967 to mid-1983, three hundred fifty surgical operations were performed on 163 patients with hemophilia A, without factor VIII inhibitor. One death occurred, in a patient with a serious head injury. Postoperative hemorrhages occurred after 23% of operations, but the incidence after surgery on the knee, 40%, was decidedly higher than the 15% incidence after operations at other sites. Concurrent plasma factor VIII levels were over 0.40 units/mL in 72% of instances and under 0.30 units/mL in only 15% of instances. The incidence of postoperative hemorrhage did not change over the study period despite a threefold increase in typical dosage of factor VIII (from 600 to 2,000 units/kg per operation) and doubling of typical trough factor VIII levels (from 0.37 units/mL to 0.70 units/mL). Circulating factor VIII levels apparently are not the sole determinants of postoperative bleeding in hemophilia A.

(JAMA 1985;253:1279-1283)



Author Affiliations

From the Departments of Medicine (Drs Kasper and Boylen), Pediatrics (Drs Ewing and Dietrich), and Orthopaedics (Drs Luck and Dietrich), University of Southern California School of Medicine, and Hemophilia Treatment Center, Orthopaedic Hospital, Los Angeles.


Footnotes

Reprint requests to Orthopaedic Hospital, 2400 S Flower St, Los Angeles, CA 90007 (Dr Kasper).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Perioperative Care of the Patient With Hemophilia Undergoing Urgent Appendectomy
Redwine and Bold
Arch Surg 2007;142:894-897.
ABSTRACT | FULL TEXT  

Hemophilic Arthropathy
Luck et al.
J Am Acad Orthop Surg 2004;12:234-245.
ABSTRACT | FULL TEXT  

General surgery in haemophiliac patients
Bastounis et al.
Postgrad. Med. J. 2000;76:494-495.
ABSTRACT | FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1985 American Medical Association. All Rights Reserved.