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A New Analysis of Old Data

Stuart T. Brown, MD; Akbar Zaidi, MS; Sandra A. Larsen, PhD; Gladys H. Reynolds, PhD

JAMA. 1985;253(9):1296-1299.

Abstract
One important aspect of the posttreatment evaluation of patients with early syphilis is assessment of serological test results. Using information previously collected from 818 patients in the Early Syphilis Study, we evaluated the seroresponse of people treated for primary or secondary syphilis. We generated curves describing the VDRL titer declines with time. The VDRL titer declined approximately fourfold at three months and eightfold at six months. These observations will allow clinicians to identify treatment failures or reinfections at the earliest possible time during their follow-up.

(JAMA 1985;253:1296-1299)

Author Affiliations
From the Division of Sexually Transmitted Diseases, Center for Prevention Services (Drs Brown and Reynolds and Mr Zaidi); and the Sexually Transmitted Diseases Laboratory Program, Center for Infectious Diseases (Dr Larsen), Centers for Disease Control, Atlanta.

Footnotes
Reprint requests to Technical Information Services, Center for Prevention Services, Centers for Disease Control, Atlanta, GA 30333 (Dr Brown).

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