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Susana C. Poliak, MD; John J. DiGiovanna, MD; Earl G. Gross, MD; Gail Gantt, RN; Gary L. Peck, MD

JAMA. 1985;254(20):2930-2932.

Abstract
After observing a patient with adult-onset tooth discoloration coincident with minocycline administration, we retrospectively surveyed a cohort of patients with severe cystic acne during therapeutic trials with isotretinoin. Four of 72 patients who had minocycline therapy during adolescence were found to have minocycline-associated tooth discoloration, which occurred in one case after only four weeks of treatment. Thus, minocycline must be considered as an uncommon cause of tooth staining in adults.

(JAMA 1985;254:2930-2932)

Author Affiliations
From the Dermatology Branch (Drs Poliak, DiGiovanna, and Peck and Ms Gantt) and the Cancer Prevention Studies Branch (Dr Gross), National Cancer Institute, Bethesda, Md.

Footnotes
Reprint requests to Dermatology Branch, National Cancer Institute, National Institutes of Health, Bldg 10, Room 12N238, Bethesda, MD 20205 (Dr DiGiovanna).

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