This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

In Vivo Imaging With Iodine 123—Labeled 3-Quinuclidinyl-4-Iodobenzilate and Emission Tomography

B. Leonard Holman, MD; Raymond E. Gibson, PhD; Thomas C. Hill, MD; William C. Eckelman, PhD; Marilyn Albert, PhD; Richard C. Reba, MD

JAMA. 1985;254(21):3063-3066.

Abstract
In vivo imaging of muscarinic acetylcholine receptor binding function in a patient with Alzheimer's disease, using single-photon emission computed tomography and iodine 123-labeled 3-quinuclidinyl-4-iodobenzilate (¹²³I-QNB), and perfusion imaging using¹²³I-N-isopropyl p-iodoamphetamine are described. A profound decrease in perfusion to the posterior temporal and parietal cortex and a more uniform uptake of¹²³I-QNB throughout the cerebral cortex were observed. The¹²³I-QNB activity ratio was reduced compared with that of a normal age-matched subject, suggesting a moderate impairment in muscarinic receptor binding function in Alzheimer's disease. Furthermore, and more importantly, our study demonstrates that images of in vivo receptor binding can be obtained easily and nontraumatically using¹²³I-QNB and single-photon emission computed tomography.

(JAMA 1985;254:3063-3066)

Author Affiliations
From the Departments of Radiology, Harvard Medical School, Brigham and Women's Hospital and New England Deaconess Hospital, Boston (Drs Holman and Hill); the Department of Radiology, George Washington University Medical Center, Washington, DC (Drs Gibson, Eckelman, and Reba); the Departments of Psychiatry and Neurology, Massachusetts General Hospital, Boston (Dr Albert); and the Division of Aging (Dr Albert), Harvard Medical School, Boston.

Footnotes
Reprint requests to Department of Radiology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (Dr Holman).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Molecular Neuroimaging: From Conventional to Emerging Techniques
Hammoud et al.
Radiology 2007;245:21-42.
ABSTRACT | FULL TEXT  

New Approaches for Determining the Site of Salivary Fluid Secretory Disorders
Baum et al.
ADR 1993;7:220-224.
ABSTRACT  

The Distribution of Cerebral Muscarinic Acetylcholine Receptors In Vivo in Patients With Dementia: A Controlled Study With 123IQNB and Single Photon Emission Computed Tomography
Weinberger et al.
Arch Neurol 1991;48:169-176.
ABSTRACT  

Single-Photon Emission Computed Tomography (SPECT) Applications and Potential
Holman and Tumeh
JAMA 1990;263:561-564.
ABSTRACT  

Research in Alzheimer's disease: A progress report
Moss
AM J ALZHEIMERS DIS OTHER DEMEN 1988;3:10-16.