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David J. Weber, MD, MPH; William A. Rutala, PhD, MPH; Gregory P. Samsa, MS; Jane E. Santimaw, RN; Stanley M. Lemon, MD

JAMA. 1985;254(22):3187-3189.

Abstract
Factors associated with lack of antibody response to the hepatitis B virus plasma vaccine were retrospectively evaluated by means of a logistic regression in 194 previously seronegative staff members of a community hospital. All subjects had received three doses of vaccine by intramuscular buttock injection using a 1-in, 23-gauge needle. Overall, only 55.7% of subjects developed detectable antibody to hepatitis B surface antigen in serum after immunization. The weight-height index served as a surrogate measure of obesity. Predictors of poor immunogenic response to hepatitis B vaccine included higher weight-height index, older age, and vaccine batch. Sex, race, timing of vaccine doses, and timing of postimmunization determination of antibody to hepatitis B surface antigen were not predictors of vaccine efficacy.

(JAMA 1985;254:3187-3189)

Author Affiliations
From the Department of Hospital Epidemiology, North Carolina Memorial Hospital (Drs Weber and Rutala, Mr Samsa, and Ms Santimaw), and the Division of Infectious Disease, Department of Medicine (Drs Weber, Rutala, and Lemon), University of North Carolina at Chapel Hill.

Footnotes
Read before the 25th Interscience Conference on Antimicrobial Agents and Chemotherapy, Minneapolis, Sept 30, 1985.

Reprint requests to Division of Infectious Diseases, University of North Carolina at Chapel Hill, 547 Clinical Sciences Bldg 229H, Chapel Hill, NC 27514 (Dr Weber).

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