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Review of the Literature and Current Status

Council on Scientific Affairs

JAMA. 1985;254(23):3353-3357.

Abstract
In response to growing public and legislative interest in organ transplantation, the American Medical Association's Council on Scientific Affairs has convened an advisory panel to prepare state-of-the-art monographs on several of the central topics. The first report of the panel, approved by the Council in February 1985, reviews the experimental work with xenografts. This report summarizes the published experience with animal and human xenografts to date and discusses the mechanisms of xenograft rejection. The report concludes that the process of xenograft rejection qualitatively resembles allograft rejection, involving both cellular and humoral immune mechanisms, but differs quantitatively depending on the genetic disparity between donor and recipient. Relative beneficial effects of various immunosuppression regimens, including cyclosporin on xenograft survival in donor recipient models with varying genetic disparity, have not yet been studied in a critical fashion.

(JAMA 1985;254:3353-3357)

Author Affiliations
From the Council on Scientific Affairs, Division of Evaluation and Nomenclature, American Medical Association, Chicago.

Footnotes
This report is not intended to be construed or to serve as a standard of medical care. Standards of medical care are determined on the basis of all of the facts and circumstances involved in an individual case and are subject to change as scientific knowledge and technology advance and patterns of practice evolve. This report reflects the views of scientific literature as of June 1985.

Reprint requests to Division of Evaluation and Nomenclature, Council on Scientific Affairs, American Medical Association, 535 N Dearborn St, Chicago, IL 60610 (John C. Ballin, PhD).

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ABSTRACT