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A Meta-analysis

Zung Vu Tran, PhD; Arthur Weltman, PhD

JAMA. 1985;254(7):919-924.

Abstract
Ninety-five studies conducted between September 1955 and October 1983 measuring changes in human serum lipid and lipoprotein levels in response to exercise training were analyzed using meta-analysis. Change in body weight during exercise training may confound observed serum lipid and lipoprotein level changes; thus, data from these studies were partitioned into those where subjects gained body weight, maintained body weight, or lost body weight. Results showed differential changes in cholesterol, triglyceride, low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol, and cholesterol/high-density lipoprotein-cholesterol levels in the three body-weight categories. Where body weight did not change, cholesterol and LDL-C levels decreased significantly (7.3 mg/dL and 3.3 mg/dL, respectively). Where body weight decreased, cholesterol and LDL-C levels also decreased significantly (13.2 mg/dL and 11.1 mg/dL, respectively). However, with body-weight increase, cholesterol and LDL-C levels increased by 2.9 mg/dL and 3.0 mg/dL, respectively. These results suggest that reductions in cholesterol and LDL-C levels were greatest when exercise training was combined with body-weight losses.

(JAMA 1985;254:919-924)

Author Affiliations
From the Measurement Lab, Department of Physical Education and Recreation, University of Colorado, Boulder (Dr Tran); and the Exercise Physiology Lab, Department of Health and Physical Education, University of Virginia, Charlottesville (Dr Weltman).

Footnotes
Reprint requests to Measurement Lab, Department of Physical Education and Recreation, Campus Box 354, University of Colorado, Boulder, CO 80309 (Dr Tran).

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