 |
 |

Human T-Cell Lymphotropic Virus Type III Infection in a Cohort of Homosexual Men in New York City
Cladd E. Stevens, MD;
Patricia E. Taylor, PhD;
Edith A. Zang, PhD;
John M. Morrison, MA;
Edward J. Harley, MS;
Santiago Rodriguez de Cordoba, PhD;
Carlos Bacino, MD;
Robert C. Y. Ting, PhD;
Anne J. Bodner, PhD;
M. G. Sarngadharan, PhD;
Robert C. Gallo, MD;
Pablo Rubinstein, MD
JAMA. 1986;255(16):2167-2172.
Abstract
 |  |
Using blood samples collected since 1978, we investigated the epidemiology of human T-cell lymphotropic virus type III (HTLV-III), the etiologic agent of the acquired immunodeficiency syndrome, in a group of 378 homosexually active men who have resided in New York City since the acquired immunodeficiency syndrome epidemic began. The anti-HTLV-III prevalence was 6.6% in sera from 1978 or 1979, and the subsequent annual incidence of seroconversion among susceptible men ranged between 5.5% and 10.6%. The highest incidences were in recent years, even though these men reported a decrease in their sexual activity during this time. These data demonstrate the continuing risk of HTLV-III infections in the homosexual population studied and emphasize the need for more effective prevention of transmission. The year during which antibody was first present was the only factor identified that was associated with altered cell-mediated immunity in antibody-positive men. Men who became antibody positive in 1981 or earlier currently had significantly lower OKT4/OKT8 ratios than did those who seroconverted more recently. Further follow-up will be necessary to establish the reasons for this association.
(JAMA 1986;255:2167-2172)
Author Affiliations
From the Wolf Szmuness Laboratory of Epidemiology (Drs Stevens, Taylor, and Zang and Messrs Morrison and Harley) and the Laboratory of immunogenetics (Drs Rodriguez de Cordoba, Bacino, and Rubinstein), Lindsley F. Kimball Research Institute, New York Blood Center, New York; the Biotech Research Laboratories, Inc, Rockville, Md (Drs Ting and Bodner); Litton Bionetics, Inc, Kensington, Md (Dr Sarngadharan); and the National Cancer Institute, Bethesda, Md (Dr Gallo).
Footnotes
Reprint requests to New York Blood Center, 310 E 67th St, New York, NY 10021 (Dr Stevens).
CiteULike Connotea Del.icio.us Digg Reddit Technorati Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
 |
From the Cover: The emergence of HIV/AIDS in the Americas and beyond
Gilbert et al.
Proc. Natl. Acad. Sci. USA 2007;104:18566-18570.
ABSTRACT
| FULL TEXT
CD4 Lymphocyte Concentrations in Patients With Newly Identified HIV Infection Attending STD Clinics: Potential Impact on Publicly Funded Health Care Resources
Hutchinson et al.
JAMA 1991;266:253-256.
ABSTRACT
Risk of Developing AIDS in HIV-Infected Cohorts of Hemophilic and Homosexual Men
Jason et al.
JAMA 1989;261:725-727.
ABSTRACT
Prostatic Cancer in a Patient with Asymptomatic HIV Infection: Are Some Liues More Equal than Others ?
Roach et al.
Med Decis Making 1988;8:132-144.
Risk of Human Immunodeficiency Virus Transmission From Heterosexual Adults With Transfusion-Associated Infections
Peterman et al.
JAMA 1988;259:55-58.
ABSTRACT
Yeast-Recombinant Hepatitis B Vaccine: Efficacy With Hepatitis B Immune Globulin in Prevention of Perinatal Hepatitis B Virus Transmission
Stevens et al.
JAMA 1987;257:2612-2616.
ABSTRACT
The Epidemiology of the Human Immunodeficiency Virus Infection
Mueller
J Law Med Ethics 1986;14:250-258.
Screening for HIV Infection: Risks, Benefits, and the Burden of Proof
Barry et al.
J Law Med Ethics 1986;14:259-267.
Sexual Transmission of Human Immunodeficiency Virus
Peterman and Curran
JAMA 1986;256:2222-2226.
ABSTRACT
HIV Antibody Screening: An Ethical Framework for Evaluating Proposed Programs
Bayer et al.
JAMA 1986;256:1768-1774.
ABSTRACT
Health Education about AIDS among Seropositive Blood Donors
Cleary et al.
Health Educ Behav 1986;13:317-329.
ABSTRACT
AIDS Risk Reduction Recommendations and Sexual Behavior Patterns among Gay Men: A Multifactorial Categorical Approach to Assessing Change
Martin
Health Educ Behav 1986;13:347-358.
ABSTRACT
|