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Long-term Effect on Somatic Growth, Bone Maturation, and Predicted Height

Florence Comite, MD; Fernando Cassorla, MD; Kevin M. Barnes; Karen D. Hench, RN, NP; Andrew Dwyer, MD; Marilyn C. Skerda, RN; D. Lynn Loriaux, MD, PhD; Gordon B. Cutler, Jr, MD; Ora H. Pescovitz, MD

JAMA. 1986;255(19):2613-2616.

Abstract
The long-acting analogue of luteinizing hormone releasing hormone, D-Trp⁶-Pro⁹-NEt-LHRH (LHRH_a), is effective in the short-term treatment of central precocious puberty. We report the results of two to four years of LHRH_a therapy in 27 children with this disorder. Secondary sex characteristics regressed in most patients. Sex steroid levels and basal and LHRH-stimulated gonadotropin levels remained suppressed compared with pretreatment values. Linear growth rates decreased from 11.0±0.8 (SEM) cm/yr before treatment to 5.7 ±0.4 cm/yr at two years of treatment and 3.7±0.7 cm/yr at four years of treatment. Predicted heights by the Bayley-Pinneau method increased from 156.4 ±2.0 cm before treatment to 162.3 ±2.3 cm at two years and 163.4 ±2.4 cm at three years. Five patients treated for four years had a mean increase in predicted height of 5.5 cm. To date no adverse effects have been observed. However, the ultimate safety of this analogue is not known. We conclude that LHRH_a appears to be an effective long-term therapy for central precocious puberty.

(JAMA 1986;255:2613-2616)

Author Affiliations
From the Developmental Endocrinology Branch, National Institute of Child Health and Human Development (Drs Comite, Cassorla, Loriaux, Cutler, and Pescovitz, and Mr Barnes), and the Clinical Center, National Institutes of Health (Dr Dwyer and Mss Hench and Skerda), Bethesda, Md.

Footnotes
Reprint requests to Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bldg 10, Room 10N262, Bethesda, MD 20892 (Dr Cutler).

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ABSTRACT