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Janine M. Jason, MD; J. Steven McDougal, MD; Gloria Dixon, RN; Dale N. Lawrence, MD; M. Susan Kennedy, MT; Margaret Hilgartner, MD; Louis Aledort, MD; Bruce L. Evatt, MD

JAMA. 1986;255(2):212-215.

Abstract
We evaluated the human T-cell lymphotropic virus type III/Iymphadenopathy-associated virus (HTLV-III/LAV) antibody and immune status of 88 persons living with and/or sexual partners of 43 hemophiliacs, 12 of whom had AIDS, five of whom had AIDS-related complex (ARC), 17 of whom were clinically well but HTLV-III/LAV antibody positive, and nine of whom were well and HTLV-III/LAV antibody negative. No nonhemophilic household contacts (0/50) of healthy hemophiliacs were HTLV-III/LAV antibody positive; two of 33 nonhemophilic AIDS/ARC contacts were positive. One was a spouse and one a sexual partner of a hemophiliac. One of these antibody-positive contacts herself had AIDS, and one had ARC. Antibody-negative, nonhemophilic contacts of AIDS/ARC and of antibody-positive hemophiliacs had significantly lower numbers of lymphocytes, T helper lymphocytes, and T suppressor lymphocytes than did contacts of antibody-negative hemophiliacs. We conclude that risk of HTLV-III/LAV transmission may exist for spouses and/or sexual contacts of hemophiliacs with AIDS/ARC, but we cannot now determine the risk for contacts of asymptomatic hemophiliacs.

(JAMA 1986;255:212-215)

Author Affiliations
From the Center for Infectious Diseases, Centers for Disease Control, Atlanta (Drs Jason, McDougal, Lawrence, and Evatt and Mss Dixon and Kennedy); and the Hemophilia Center, New York Hospital-Cornell Medical Center (Dr Hilgartner) and the Mount Sinai School of Medicine (Dr Aledort), New York.

Footnotes
Reprint requests to Centers for Disease Control, 1600 Clifton Rd, 1-1407, Atlanta, GA 30333 (Dr Jason).

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