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Embolization of the Hepatic Artery With Polyvinyl Sponge and Cisplatin

C. Humberto Carrasco, MD; Sidney Wallace, MD; Chuslip Charnsangavej, MD; Nicholas E. J. Papadopoulos, MD; Yehuda Z. Patt, MD; Giora M. Mavligit, MD

JAMA. 1986;255(22):3152-3154.

Abstract
Patients with ocular melanoma have a high incidence of hepatic metastases, which primarily determine their length of survival. In an attempt to control the neoplastic disease in the liver, embolization of the hepatic artery with a combination of polyvinyl sponge (Ivalon) and a suspension of cisplatin was performed in two patients with hepatic metastases from ocular melanoma. Dramatic regression of the hepatic metastases, lasting 19 and six months, occurred in these two patients after one or two such treatments. Our preliminary, albeit successful, experience with this therapeutic approach suggests that it may offer relatively prolonged periods of remission and warrants further investigation.

(JAMA 1986;255:3152-3154)

Author Affiliations
From the Departments of Diagnostic Radiology (Drs Carrasco, Wallace, and Charnsangavej), Medical Oncology (Dr Papadopoulos), and Clinical Immunology (Drs Patt and Mavligit), University of Texas M. D. Anderson Hospital and Tumor Institute at Houston.

Footnotes
Reprint requests to Department of Diagnostic Radiology, University of Texas M. D. Anderson Hospital and Tumor Institute, 6723 Bertner, Houston, TX 77030 (Dr Carrasco).

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