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Alfred W. Kopf, MD; Laura J. Hellman, MD; Gary S. Rogers, MD; Dennis F. Gross, MD; Darrell S. Rigel, MD; Robert J. Friedman, MD; Marcia Levenstein, DSc; Julian Brown; Frederick M. Golomb, MD; Daniel F. Roses, MD; Stephen L. Gumport, MD; Medwin M. Mintzis, MD

JAMA. 1986;256(14):1915-1919.

Abstract
Characteristics associated with familial compared with nonfamilial malignant melanoma were assessed. These data were obtained from consecutive prospectively completed questionnaires on 1169 cases of cutaneous malignant melanoma. Of these, 69 patients indicated a positive family history for this cancer. Among the various clinical and histological variables compared, those that significantly correlated with the familial occurrence of malignant melanoma include younger age at first diagnosis, smaller diameter of the lesion, lower Clark level, decreased frequency of nonmelanoma skin cancer, and reduced prevalence of noncutaneous cancer. Increased awareness of malignant melanoma among family members could account for some of these observations. Identification of the familial variety of malignant melanoma has practical implications concerning early detection and prompt intervention.

(JAMA 1986;256:1915-1919)

Author Affiliations
From the New York University Melanoma Cooperative Group (Drs Kopf, Rogers, Rigel, Friedman, Levenstein, Golomb, Roses, Gumport, and Mintzis); and the Departments of Dermatology (Drs Kopf, Hellman, Rogers, Gross, Rigel, Friedman, and Mintzis and Mr Brown) and Surgery (Drs Golomb, Roses, and Gumport), New York University School of Medicine, New York.

Footnotes
Reprints not available.

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