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Deborah A. Reed, MD; Sidney H. Schnoll, MD, PhD

JAMA. 1986;256(18):2562-2564.

Abstract
The combination of pentazocine hydrochloride and tripelennamine hydrochloride (T's and blues) has been abused as a heroin substitute. In response to this abuse, the formulation of pentazocine has been changed to include naloxone hydrochloride, a short-acting narcotic antagonist, in the tablet (Talwin Nx). Two cases of abuse of the new pentazocine and naloxone formulation along with tripelennamine are reported. Potential reasons for the failure of naloxone to block the effects of pentazocine are discussed.

(JAMA 1986;256:2562-2564)

Author Affiliations
From the Departments of Psychiatry and Behavioral Sciences (Drs Reed and Schnoll) and Pharmacology (Dr Schnoll), Northwestern University Medical School, Chicago.

Footnotes
Reprint requests to 215 E Chicago Ave, Suite 905, Chicago, IL 60611 (Dr Schnoll).

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