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An Interim Report

Donald G. Patterson, Jr, PhD; Richard E. Hoffman, MD; Larry L. Needham, PhD; Daryl W. Roberts, MEd; John R. Bagby, PhD; James L. Pirkle, MD; Henry Falk, MD; Eric J. Sampson, PhD; Vernon N. Houk, MD

JAMA. 1986;256(19):2683-2686.

Abstract
The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin, commonly known as dioxin, was measured in the adipose tissue of 39 persons with a history of residential, recreational, or occupational exposure in Missouri and in 57 persons in a control group. All participants had detectable levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in their adipose tissue, but the exposed group had significantly higher levels. Levels of six of the exposed persons were more than five times greater than the level of the highest control. Measuring 2,3,7,8-tetrachlorodibenzo-p-dioxin in adipose tissue provides a much improved index of exposure, an important advance for research studies evaluating the possible health effects of this compound.

(JAMA 1986;256:2683-2686)

Author Affiliations
From the Center for Environmental Health, Centers for Disease Control, Atlanta (Drs Patterson, Hoffman, Needham, Pirkle, Falk, Sampson, and Houk); and the Missouri Department of Health, Division of Environmental Health and Epidemiology Services, Jefferson City (Dr Bagby and Mr Roberts).

Footnotes
Reprint requests to Toxicology Branch, Division of Environmental Health and Laboratory Science, Centers for Disease Control, Atlanta, GA 30333 (Dr Patterson).

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