This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (94)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

A Six-Year Study of the Effects of an Environmental Disaster Near Seveso, Italy

Paolo Mocarelli, MD, PhD; Alessandro Marocchi, MD; Paolo Brambilla, MD; PierMario Gerthoux, PhD; Donald S. Young, MB, PhD; Nathan Mantel, MA

JAMA. 1986;256(19):2687-2695.

Abstract
Following a major environmental accident near Seveso, Italy, on July 10, 1976, we attempted to determine if the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) released into the atmosphere had any effect on the liver function and lipid metabolism of exposed children. From July 1976 to June 1982, we analyzed the results of more than 4500 laboratory tests (alanine aminotransferase, aspartate aminotransferase, -glutamyltransferase, alkaline phosphatase, cholesterol, and triglycerides in plasma and -aminolevulinic acid in urine) in a population of about 1500 children aged 6 to 10 years at the moment of the accident. The children exposed to the highest concentration of TCDD showed alterations in serum -glutamyltransferase and alanine aminotransferase activity compared with the control group. These differences were restricted to values inside limits set from the lower end of the normal range to slightly above it. The observed abnormalities were slight and disappeared with time.

(JAMA 1986;256:2687-2695)

Author Affiliations
From the Department of Clinical Pathology, Hospital of Desio (Drs Mocarelli, Marocchi, Brambilla, and Gerthoux), and the Institute of General Pathology, University of Milano (Dr Mocarelli), Milan, Italy; the Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia (Dr Young); and the Department of Mathematics, Statistics and Computer Science, The American University, Bethesda, Md (Mr Mantel).

Footnotes
Reprint requests to Department of Clinical Pathology, Desio Hospital, 20033 Desio, Milan, Italy (Dr Mocarelli).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Mortality in a Population Exposed to Dioxin after the Seveso, Italy, Accident in 1976: 25 Years of Follow-Up
Consonni et al.
Am J Epidemiol 2008;167:847-858.
ABSTRACT | FULL TEXT  

Effects of Subchronic Exposure to a Complex Mixture of Persistent Contaminants in Male Rats: Systemic, Immune, and Reproductive Effects
Wade et al.
Toxicol Sci 2002;67:131-143.
ABSTRACT | FULL TEXT  

Health Effects of Dioxin Exposure: A 20-Year Mortality Study
Bertazzi et al.
Am J Epidemiol 2001;153:1031-1044.
ABSTRACT | FULL TEXT  

Serum Levels of TCDD and Dioxin-like Chemicals in Rhesus Monkeys Chronically Exposed to Dioxin: Correlation of Increased Serum PCB Levels with Endometriosis
Rier et al.
Toxicol Sci 2001;59:147-159.
ABSTRACT | FULL TEXT  

Regulations and Advisories
Toxicol Ind Health 2000;16:173-201.
 

Dioxin and Dioxin-Like Compounds in Soil, Part II: Technical Support Document for ATSDR Interim Policy Guideline
De Rosa et al.
Toxicol Ind Health 1997;13:769-804.
 

Hepatic and Gastrointestinal Effects in an Occupational Cohort Exposed to 2,3,7,8-Tetrachlorodibenzo-para-dioxin
Calvert et al.
JAMA 1992;267:2209-2214.
ABSTRACT  

Polychlorinated Dibenzo-p-dioxins and Polychlorinated Dibenzofurans: The Risks to Human Health. A Review
Skene et al.
Hum Exp Toxicol 1989;8:173-203.
ABSTRACT  

Preliminary Report: 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure to Humans--Seveso, Italy
Arch Dermatol 1989;125:329-330.
ABSTRACT  

Preliminary Report: 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure to Humans--Seveso, Italy
JAMA 1989;261:831-832.