Therapeutic response to lovastatin (mevinolin) in nonfamilial hypercholesterolemia. A multicenter study. The Lovastatin Study Group II

Lovastatin (mevinolin), a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, was investigated in a double-blind, placebo-controlled multicenter study of 101 patients with nonfamilial primary hypercholesterolemia. Dosages varied from 10 to 80 mg/d in single or divided doses. Patients receiving 40 mg twice a day experienced mean total and low-density lipoprotein cholesterol reductions of 32% and 39%, respectively. High-density lipoprotein cholesterol levels tended to rise slightly and plasma triglyceride levels were moderately decreased. Adverse effects attributable to lovastatin were infrequent and no patient was withdrawn from therapy. In this study, lovastatin was a well tolerated and effective agent for the treatment of nonfamilial hypercholesterolemia.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Efficacy and Safety of Lovastatin Therapy in Adolescent Girls With Heterozygous Familial Hypercholesterolemia
Clauss et al.
Pediatrics 2005;116:682-688.
ABSTRACT | FULL TEXT  

Efficacy of Extended-Release Niacin With Lovastatin for Hypercholesterolemia: Assessing All Reasonable Doses With Innovative Surface Graph Analysis
Insull et al.
Arch Intern Med 2004;164:1121-1127.
ABSTRACT | FULL TEXT  

Effects of Atorvastatin on the Intracellular Stability and Secretion of Apolipoprotein B in HepG2 Cells
Mohammadi et al.
Arterioscler. Thromb. Vasc. Bio. 1998;18:783-793.
ABSTRACT | FULL TEXT  

Treating Hyperlipidemia for the Primary Prevention of Coronary Disease: Are Higher Dosages of Lovastatin Cost-effective?
Perreault et al.
Arch Intern Med 1998;158:375-381.
ABSTRACT | FULL TEXT  

Lovastatin Decreases De Novo Cholesterol Synthesis and LDL Apo B-100 Production Rates in Combined-Hyperlipidemic Males
Cuchel et al.
Arterioscler. Thromb. Vasc. Bio. 1997;17:1910-1917.
ABSTRACT | FULL TEXT  

A Randomized Multicenter Trial Comparing the Efficacy of Simvastatin and Fluvastatin
Illingworth et al.
J CARDIOVASC PHARMACOL THER 1996;1:23-29.
ABSTRACT  

The Efficacy of Intensive Dietary Therapy Alone or Combined with Lovastatin in Outpatients with Hypercholesterolemia
Hunninghake et al.
NEJM 1993;328:1213-1219.
ABSTRACT | FULL TEXT  

Evaluation and Treatment of Hypercholesterolemia
Talbert
Journal of Pharmacy Practice 1988;1:100-110.