Therapeutic response to lovastatin (mevinolin) in nonfamilial hypercholesterolemia. A multicenter study. The Lovastatin Study Group II
Lovastatin (mevinolin), a potent inhibitor of 3-hydroxy-3-methylglutaryl
coenzyme A reductase, was investigated in a double-blind,
placebo-controlled multicenter study of 101 patients with nonfamilial
primary hypercholesterolemia. Dosages varied from 10 to 80 mg/d in single
or divided doses. Patients receiving 40 mg twice a day experienced mean
total and low-density lipoprotein cholesterol reductions of 32% and 39%,
respectively. High-density lipoprotein cholesterol levels tended to rise
slightly and plasma triglyceride levels were moderately decreased. Adverse
effects attributable to lovastatin were infrequent and no patient was
withdrawn from therapy. In this study, lovastatin was a well tolerated and
effective agent for the treatment of nonfamilial hypercholesterolemia.
Efficacy and Safety of Lovastatin Therapy in Adolescent Girls With Heterozygous Familial Hypercholesterolemia
Clauss et al.
Pediatrics 2005;116:682-688.
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Efficacy of Extended-Release Niacin With Lovastatin for Hypercholesterolemia: Assessing All Reasonable Doses With Innovative Surface Graph Analysis
Insull et al.
Arch Intern Med 2004;164:1121-1127.
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Effects of Atorvastatin on the Intracellular Stability and Secretion of Apolipoprotein B in HepG2 Cells
Mohammadi et al.
Arterioscler. Thromb. Vasc. Bio. 1998;18:783-793.
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Treating Hyperlipidemia for the Primary Prevention of Coronary Disease: Are Higher Dosages of Lovastatin Cost-effective?
Perreault et al.
Arch Intern Med 1998;158:375-381.
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Lovastatin Decreases De Novo Cholesterol Synthesis and LDL Apo B-100 Production Rates in Combined-Hyperlipidemic Males
Cuchel et al.
Arterioscler. Thromb. Vasc. Bio. 1997;17:1910-1917.
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A Randomized Multicenter Trial Comparing the Efficacy of Simvastatin and Fluvastatin
Illingworth et al.
J CARDIOVASC PHARMACOL THER 1996;1:23-29.
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The Efficacy of Intensive Dietary Therapy Alone or Combined with Lovastatin in Outpatients with Hypercholesterolemia
Hunninghake et al.
NEJM 1993;328:1213-1219.
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Evaluation and Treatment of Hypercholesterolemia
Talbert
Journal of Pharmacy Practice 1988;1:100-110.