This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (35)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

James R. Campbell, MD; Thomas W. Clarkson, PhD; Mark D. Omar

JAMA. 1986;256(22):3127-3130.

Abstract
Two patients had heavy metal intoxication resulting from industrial exposure to mercury vapors. One patient remained asymptomatic despite high urinary mercury levels. The second presented with a documented toxic reaction, including abnormal electromyograms and hematuria. Treatment was begun with 2,3-dimercaptopropane-1-sulfonate, an investigational drug used under Food and Drug Administration guidelines (IND 19 276). Use in both patients resulted in a dramatic change in excretion half-life of the mercury, from 33.1 days before treatment to 11.2 days during therapy. No significant toxic effects related to drug therapy were observed. Clearing of hematuria and reversal of electromyographic abnormalities were prompt in the symptomatic patient. Therapy with 2,3-dimercaptopropane-1-sulfonate was effective in these two patients.

(JAMA 1986;256:3127-3130)

Author Affiliations
From the Department of Internal Medicine, University of Nebraska Medical Center, Omaha (Dr Campbell and Mr Omar); and the Department of Toxicology, University of Rochester (NY) School of Medicine (Dr Clarkson).

Footnotes
Reprint requests to Department of Internal Medicine, University of Nebraska Medical Center, 42nd and Dewey Avenue, Omaha, NE 68105 (Dr Campbell).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

DMPS (2,3-Dimercaptopropane-1-sulfonate, Dimaval) Decreases the Body Burden of Mercury in Humans Exposed to Mercurous Chloride
Gonzalez-Ramirez et al.
J. Pharmacol. Exp. Ther. 1998;287:8-12.
ABSTRACT | FULL TEXT  

DMSA Administration to Patients with Alleged Mercury Poisoning from Dental Amalgams: A Placebo-controlled Study
Sandborgh Englund et al.
JDR 1994;73:620-628.
ABSTRACT  

Toxicity From Vacuumed Mercury: A Household Hazard
Zelman et al.
CLIN PEDIATR 1991;30:121-123.