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  Vol. 256 No. 22, December 12, 1986 TABLE OF CONTENTS
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The Need to Treat Mild Hypertension

Misinterpretation of Results From the Australian Trial

John D. Abernethy, MB, CLB

JAMA. 1986;256(22):3134-3137.


Abstract

Despite the clear-cut result of the Australian Therapeutic Trial in Mild Hypertension, which demonstrated prospectively the benefit of treatment of diastolic blood pressure in the range of 95 to 109 mm Hg, a retrospective analysis that classified subjects by the average diastolic pressure level attained during the trial purported to show an absence of treatment benefit at lower average diastolic pressures and a negative treatment effect at higher levels. However, the method of classification by average attained diastolic pressure introduced substantial selection bias, invalidating the retrospective analysis and rendering as spurious both the deleterious treatment effect and its lack of efficacy at lower diastolic levels.

(JAMA 1986;256:3134-3137)



Author Affiliations

From the Department of Medicine, University of Mississippi Medical Center, Jackson. Dr Abernethy is now with the Division of Public Health, School of Health Sciences, University of Massachusetts, Amherst.


Footnotes

Reprint requests to Division of Public Health, School of Health Sciences, University of Massachusetts, Amherst, MA 01003 (Dr Abernethy).



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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

National High Blood Pressure Education Program Working Group Report on Primary Prevention of Hypertension
Arch Intern Med 1993;153:186-208.
ABSTRACT  

Cardiovascular Morbidity in Relation to Change in Blood Pressure and Serum Cholesterol Levels in Treated Hypertension: Results From the Primary Prevention Trial in Goteborg, Sweden
Samuelsson et al.
JAMA 1987;258:1768-1776.
ABSTRACT  





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