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Toshihide Yamamoto, MD; Masanori Shimizu, MD; Masahiro Morioka, MD; Mitsuo Kitano, MD; Hirokazu Wakabayashi, MD; Nobuyuki Aizawa, MD

JAMA. 1986;256(5):604-608.

Abstract
The relation of thirst to the renin-angiotensin system was examined in 38 patients with chronic renal failure receiving hemodialysis treatment. They were classified into three groups, ie, group 1(19 patients), no or modest thirst; group 2 (13 patients), moderate thirst; and group 3 (six patients), excessive thirst. The plasma renin activity, plasma angiotensin II levels, and interdialytic weight gains of groups 1 to 3 significantly increased in a progressive manner with intensity of thirst. The hyperdipsia experienced by four patients in group 3 ameliorated after administration of an angiotensin-converting-enzyme inhibitor. The hyperdipsia of some patients with chronic renal failure therefore appears to be mediated by increased production of endogenous angiotensin II.

(JAMA 1986;256:604-608)

Author Affiliations
From the Departments of Internal Medicine, Kishiwada Tokushukai Hospital (Drs Yamamoto and Wakabayashi), Osaka; Yamato Tokushukai Hospital (Dr Shimizu), Yamato-koriyama; Hanyu Seikyo Hospital (Dr Morioka); Yao Tokushukai Hospital (Dr Kitano); and Chigasaki Tokushukai Hospital (Dr Aizawa), Japan.

Footnotes
Presented in part at the 15th International Congress of the International Society of Psychoneuroendocrinology, Vienna, July 17, 1984.

Reprint requests to the Department of Internal Medicine, Kishiwada Tokushukai Hospital, 4-22-38 Isonokamicho, Kishiwada, Osaka 596, Japan (Dr Yamamoto).

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