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Bruno H. Ch. Stricker, MB; Herman S. F. Heijermans, MD; Hans Braat, MD; Johannes Norg, MD

JAMA. 1986;256(5):619-620.

Abstract
Fever caused by [β-adrenoceptor blocking agents is rare. We describe fever in two patients who had been treated with labetalol. In both patients, two challenge periods were rapidly followed by a relapse, whereas on each occasion there was normalization of temperature after discontinuation of the drug therapy. This reaction is rare and unpredictable. Because there was a clear sensitization period of three to four weeks, dose independency, and an accelerated reaction to rechallenge, this adverse effect seems to be caused by an immunoallergic reaction.

(JAMA 1986;256:619-620)

Author Affiliations
From the Netherlands Center for Monitoring of Adverse Reactions to Drugs, Leidschendam (Dr Stricker), and the Department of Internal Medicine, Streekziekenhuis "Het Nieuwe Spittaal," Warnsveld (Dr Heijermans) and Zutphen (Drs Braat and Norg), the Netherlands.

Footnotes
Reprint requests to Netherlands Center for Monitoring of Adverse Reactions to Drugs, PO Box 439, 2260 AK Leidschendam, the Netherlands (Dr Stricker).

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