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The Role of the Sympathetic Nervous System

Michael A. Brodsky, MD; David A. Sato, MD; Lloyd T. Iseri, MD; Larry J. Wolff, MD; Byron J. Allen, MD

JAMA. 1987;257(15):2064-2067.

Abstract
Psychological stress has been reported to be a risk factor for sudden cardiac death in individuals both with and without underlying structural heart disease. From a group of 80 patients presenting with life-threatening ventricular tachyarrhythmia, six were identified without underlying structural heart disease. Five of these six patients experienced marked psychological stress. Each of these five patients underwent arrhythmia evaluation, demonstrating recurrent rapid monomorphic ventricular tachycardia related to changes in tone of the sympathetic nervous system. Subsequently, solitary β-adrenergic blocker therapy was given to each patient. During therapy, four of the five patients had a marked reduction of both arrhythmia and symptoms during a follow-up ranging from 29 to 49 (mean, 38) months.

(JAMA 1987;257:2064-2067)

Author Affiliations
From the Cardiology Division, Department of Medicine, University of California at Irvine, Medical Center, Orange.

Footnotes
Reprint requests to University of California at Irvine, Medical Center, 101 City Dr S, Orange, CA 92668 (Dr Brodsky).

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