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The San Francisco Men's Health Study

William Lang, MD; Robert E. Anderson, MD; Herbert Perkins, MD; Robert M. Grant; David Lyman, MD, MPH; Warren Winkelstein, Jr, MD, MPH; Rachel Royce, MPH; Jay A. Levy, MD

JAMA. 1987;257(3):326-330.

Abstract
Forty-nine percent of homosexual/bisexual men were positive for antibody to the human immunodeficiency virus (HIV) in a population-based probability sample of 1034 single men recruited from San Francisco. All heterosexual men were negative. Among seropositive men, marked lymphadenopathy was present in 29%, and 16% had at least two other symptoms or signs suggestive of HIV infection. However, lymphadenopathy alone failed to indicate severity of immune impairment. The occurrence of two or more clinical signs and symptoms, except for marked lymphadenopathy, correlated with HIV infection, diminished skin test reactivity, and reduction in Leu 3a T cells. Twenty-nine percent of seropositive men had fewer than 400 absolute Leu 3a T helper cells per microliter (<0.4x10⁹/L). Seronegative homosexual/bisexual men did not differ from heterosexual men in any clinical or laboratory variables except for increased numbers of suppressor Leu 2a T suppressor cells per microliter.

(JAMA 1987;257:326-330)

Author Affiliations
From the Children's Hospital of San Francisco (Drs Lang and Anderson); the Irwin Memorial Blood Bank, San Francisco (Dr Perkins); the School of Public Health, University of California, Berkeley (Drs Lyman and Winkelstein, Mr Grant, and Ms Royce); and the Cancer Research Institute, University of California, San Francisco (Dr Levy).

Footnotes
Reprint requests to School of Public Health, University of California, Berkeley, CA 94720 (Dr Winkelstein).

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