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Hiroshi Okayama, MD; Takashi Aikawa, MD; Michiko Okayama, MD; Hidetada Sasaki, MD; Suetsugu Mue, MD; Tamotsu Takishima, MD

JAMA. 1987;257(8):1076-1078.

Abstract
The bronchodilating effect of magnesium sulfate (MgSO₄) was studied in ten asthmatic patients with mild attacks. In five patients, 0.5 mmol/min of MgSO₄ was administered intravenously for 20 minutes, and the time courses of respiratory resistance, forced vital capacity, and forced expiratory volume at 1 s were studied. In another five patients, MgSO₄ dose-response curves were obtained. Soon after administration began, MgSO₄ relieved bronchoconstriction in a dose-dependent manner. Maximum responses (mean ± SE) of respiratory resistance, forced vital capacity, and forced expiratory volume were 71% ±3%, 117% ±5%, and 118%±1% of initial values, respectively, and were similar to the effects of additional albuterol inhalation. The infusion of MgSO₄ also improved dyspnea and piping rales in three other asthmatic patients with a severe attack. We conclude that intravenous infusion of MgSO₄ produces a rapid and marked bronchodilation in both mild and severe asthma and may be a unique bronchodilating agent.

(JAMA 1987;257:1076-1078)

Author Affiliations
From the First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.

Footnotes
Reprint requests to First Department of Internal Medicine, Tohoku University School of Medicine, Seiryomachi 1-1, Sendai 980, Japan (Dr Takishima).

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