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Kristine L. MacDonald, MD; Mitchell L. Cohen, MD; Nancy T. Hargrett-Bean, PhD; Joy G. Wells, MS; Nancy D. Puhr; Sheila F. Collin; Paul A. Blake, MD, MPH

JAMA. 1987;258(11):1496-1499.

Abstract
Changes were examined that occurred in the antimicrobial susceptibility between 1979-1980 and 1984-1985 of Salmonella organisms isolated from humans who resided in a random sample of counties in the United States. Resistance to one or more antimicrobials rose significantly from 16% (82 of 511 isolates) in 1979-1980 to 24% (117 of 485 isolates) in 1984-1985. In addition, statistically significant increases occurred in the proportion of organisms resistant to only one antimicrobial (from 4% to 9%), the rate of resistance of Salmonella typhimurium (from 14% to 26%), and the rate of resistance to tetracycline. For one commonly occurring serotype, Salmonella heidelberg, the proportion of resistant strains fell significantly from 67% in 1979-1980 to 35% in 1984-1985. When epidemiologic characteristics of patients were examined, previous use of antimicrobials for treatment of other illnesses was a significant risk factor for acquiring clinically important infections with antimicrobial-resistant Salmonella. Changes detected in the antimicrobial resistance of Salmonella during this time will ultimately affect the efficacy of antimicrobial therapy in treating human disease.

(JAMA 1987;258:1496-1499)

Author Affiliations
From the Enteric Diseases Branch, Division of Bacterial Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta. Dr MacDonald is now with the Minnesota Department of Health, Minneapolis.

Footnotes
Reprint requests to Enteric Diseases Branch, Centers for Disease Control, Atlanta, GA 30333 (Dr MacDonald).

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