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Report I, Part II, of the Allergy Panel

Council on Scientific Affairs

JAMA. 1987;258(11):1505-1508.

Abstract
The first article in this series discussed the importance of properly designed clinical trials to validate various diagnostic and therapeutic procedures and also described clinically accepted and proved tests. This article discusses other challenge tests and unproved procedures. The value of provocation-neutralization procedures has been controversial; two promising clinical models have been developed that may allow definitive trials of efficacy. Immunotherapy with allergenic extracts has been shown to be a safe and effective procedure in carefully selected patients treated with potent, well-standardized antigens administered in adequate dosage. It has been proposed that many nonspecific signs or symptoms could be caused by exposure to Candida albicans or low-dose environmental substances. The cause-and-effect relationships between exposure to C albicans or other environmental substances and the disorders that are alleged to be associated with them are, for the most part, unproved.

(JAMA 1987;258:1505-1508)

Author Affiliations
From the Council on Scientific Affairs, American Medical Association, Chicago.

Footnotes
This report was submitted to the AMA House of Delegates in December 1986 as an informational report.

This report is not intended to be construed or to serve as a standard of medical care. Standards of medical care are determined on the basis of all of the facts and circumstances involved in an individual case and are subject to chage as scientific knowledge and technology advance and patterns of practice evolve. This report reflects the views of the scientific literature as of December 1986.

Reprint requests to Council on Scientific Affairs, American Medical Association, 535 N Dearborn St, Chicago, IL 60610 (William R. Hendee, PhD).

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