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Results From the Primary Prevention Trial in Göteborg, Sweden

Ola Samuelsson, MD, PhD; Lars Wilhelmsen, MD, PhD; Ove K. Andersson, MD, PhD; Kjell Pennert, PhD; Göran Berglund, MD, PhD

JAMA. 1987;258(13):1768-1776.

Abstract
The relationship of cardiovascular disease (CVD) to the control of blood pressure (BP) and serum cholesterol levels was studied in 686 treated, middle-aged hypertensive men whose condition was followed up for 12 years. Both mean in-study BP (P<.001) and serum cholesterol levels (P<.001) were better predictors for CVD than the respective entry levels (both not significant) in multivariate analysis. Surprisingly, for mean in-study systolic and diastolic BP there seemed to be a level (approximately 150 and 85 mm Hg, respectively) below which further reduction of BP had no additional benefit from treatment. Analyses of CVD morbidity in relationship to changes in BP and serum cholesterol levels clearly showed that a combined reduction of both risk factors was necessary to achieve a substantial reduction in morbidity. These study findings indicate that (1) it may be unfavorable to reduce BP below a certain level in middle-aged hypertensive men; and (2) other risk factor interventions must be improved to improve the patient's prognosis.

(JAMA 1987;258:1768-1776)

Author Affiliations
From the Section of Preventive Medicine, Department of Medicine I, Sahlgrenska (Drs Samuelsson, Andersson, Pennert, and Berglund) and Östra (Dr Wilhelmsen) Hospitals, University of Göteberg, Sweden.

Footnotes
Reprint requests to Hypertension Unit, Department of Medicine I, Sahlgrenska Hospital, S-413 45 Göteborg, Sweden (Dr Samuelsson).

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