This Article  • References  • Full text PDF  • Correction  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Thomas A. Peterman, MD, MSc; Rand L. Stoneburner, MD, MPH; James R. Allen, MD, MPH; Harold W. Jaffe, MD; James W. Curran, MD, MPH

JAMA. 1988;259(1):55-58.

Abstract
The risk of human immunodeficiency virus (HIV) transmission was studied by interviewing and testing the serum of heterosexual contacts and casual family contacts of adults with transfusion-associated HIV infections. Two (8%) of 25 husbands and ten (18%) of 55 wives who had had sexual contact with infected spouses were seropositive for HIV. Compared with seronegative wives, the seropositive wives were older (median ages, 54 and 62 years; P=.08) and actually reported somewhat fewer sexual contacts with their infected husbands (means, 156 and 82; P>.1). There was no difference in the types of sexual contact or methods of contraception of the seropositive and seronegative spouses. There was no evidence of HIV transmission to the 63 other family members. Although most husbands and wives remained uninfected despite repeated sexual contact without protection, some acquired infection after only a few contacts. This is consistent with an as yet unexplained biologic variation in transmissibility or susceptibility.

(JAMA 1988;259:55-58)

Author Affiliations
From the AIDS Program, Center for Infectious Diseases, Centers for Disease Control, Atlanta (Drs Peterman, Allen, Jaffe, and Curran); and the Bureau of Preventable Diseases, New York City Health Department (Dr Stoneburner). Dr Peterman is now with the National Institute for Allergy and Infectious Disease, Bethesda, Md.

Footnotes
Use of trade names is for identification purposes only and does not constitute endorsement by the Public Health Service or the US Department of Health and Human Services.

Reprint requests to the AIDS Program, Centers for Disease Control, Atlanta, GA 30333 (Dr Curran).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Fewer partners or more condoms? Modelling the effectiveness of STI prevention interventions
Garnett et al.
Sex. Transm. Infect. 2008;84:ii4-ii11.
ABSTRACT | FULL TEXT  

Detection of Acute Infections during HIV Testing in North Carolina
Pilcher et al.
NEJM 2005;352:1873-1883.
ABSTRACT | FULL TEXT  

Postexposure Prophylaxis in Children and Adolescents for Nonoccupational Exposure to Human Immunodeficiency Virus
Havens and Committee on Pediatric AIDS
Pediatrics 2003;111:1475-1489.
ABSTRACT | FULL TEXT  

HIV-1 transmission and acute HIV-1 infection
Hansasuta and Rowland-Jones
Br Med Bull 2001;58:109-127.
ABSTRACT | FULL TEXT  

ART in HIV-infected couples: Has the time come for a change of attitude?
Englert et al.
Hum Reprod 2001;16:1309-1315.
ABSTRACT | FULL TEXT  

Effect of Condoms on Reducing the Transmission of Herpes Simplex Virus Type 2 From Men to Women
Wald et al.
JAMA 2001;285:3100-3106.
ABSTRACT | FULL TEXT  

Relation Between Herpes Simplex Viruses and Human Immunodeficiency Virus Infections
Severson and Tyring
Arch Dermatol 1999;135:1393-1397.
ABSTRACT | FULL TEXT  

Frequent Recovery of HIV-1 From Genital Herpes Simplex Virus Lesions in HIV-1-Infected Men
Schacker et al.
JAMA 1998;280:61-66.
ABSTRACT | FULL TEXT  

Postcoital Vaginal Bleeding as a Risk Factor for Transmission of the Human Immunodeficiency Virus in a Heterosexual Partner Study in Brazil
Guimaraes et al.
Arch Intern Med 1997;157:1362-1368.
ABSTRACT  

Sexual Transmission of HIV
Royce et al.
NEJM 1997;336:1072-1078.
FULL TEXT  

Postexposure Treatment of People Exposed to the Human Immunodeficiency Virus through Sexual Contact or Injection-Drug Use
Katz and Gerberding
NEJM 1997;336:1097-1100.
FULL TEXT  

Implications of Increased Infectivity in Early-Stage HIV Infection: Application of a Bernoulli-Process Model of HIV Transmission
Pinkerton and Abramson
Eval Rev 1996;20:516-540.
ABSTRACT  

HIV Transmission Through Donor Artificial Insemination
Araneta et al.
JAMA 1995;273:854-858.
ABSTRACT  

HIV Testing, Counseling, and Prophylaxis After Sexual Assault
Gostin et al.
JAMA 1994;271:1436-1444.
ABSTRACT  

The estimation of the basic reproduction number for infectious diseases
Dietz
Stat Methods Med Res 1993;2:23-41.
ABSTRACT  

Female-to-Male Transmission of HIV
Haverkos and Battjes
JAMA 1992;268:1855-1855.
ABSTRACT  

Man-to-Woman Sexual Transmission of the Human Immunodeficiency Virus: Risk Factors Related to Sexual Behavior, Man's Infectiousness, and Woman's Susceptibility
Lazzarin et al.
Arch Intern Med 1991;151:2411-2416.
ABSTRACT  

Female-to-Male Transmission of Human Immunodeficiency Virus
Padian et al.
JAMA 1991;266:1664-1667.
ABSTRACT  

The Challenge of Limiting the Spread of Human Immunodeficiency Virus by Controlling Other Sexually Transmitted Diseases
Kirby et al.
Arch Dermatol 1991;127:237-242.
ABSTRACT  

Intraoperative Autotransfusion in Vascular Surgery
Reddy et al.
Arch Surg 1990;125:1012-1016.
ABSTRACT  

Sexual Behavior and the Risk of HIV Infection
McCOY et al.
American Behavioral Scientist 1990;33:432-450.
 

Disinfection of Goldmann Tonometers Against Human Immunodeficiency Virus Type 1
Pepose et al.
Arch Ophthalmol 1989;107:983-985.
ABSTRACT  

Preventing the Heterosexual Spread of AIDS
Padian and Francis
JAMA 1988;260:1879-1879.
ABSTRACT  

The Epidemiology of Acquired Immunodeficiency Syndrome Among Heterosexuals
Haverkos and Edelman
JAMA 1988;260:1922-1929.
ABSTRACT  

Preventing the Heterosexual Spread of AIDS: Are We Giving Our Patients the Best Advice?
Hearst and Hulley
JAMA 1988;259:2428-2432.
ABSTRACT  

Do Alternate Modes for Transmission of Human Immunodeficiency Virus Exist? A Review
Lifson
JAMA 1988;259:1353-1356.
ABSTRACT