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Outbreak of Hypersensitivity Pneumonitis in an Industrial Setting
Elizabeth D. Woodard, MD;
Barry Friedlander, MD;
Robert J. Lesher, PhD;
Wallace Font, MD;
Richard Kinsey;
F. Terry Hearne, MS
JAMA. 1988;259(13):1965-1969.
Abstract
Symptoms consistent with hypersensitivity pneumonitis developed in several workers in two multistory buildings in an industrial complex. A health questionnaire survey was conducted to determine the extent of the problem. Eighty-seven percent of the population of 1050 employees completed the health questionnaire. Serological testing identified 152 positive precipitin reactors to the fungus Aureobasidium pullulans; 115 reactors were symptomatic. The clinical and laboratory features at the time of the acute illness and during four years of follow-up are described. The agent, A pullulans, was identified as a contaminant of the heating-cooling ventilation units containing open water-spray chambers. Control was accomplished by replacement of the ventilation systems. A secondary source of antigen was found to be corrugated cardboard. Some sensitized employees required removal from work exposure to corrugated cardboard to prevent recurrent symptoms.
(JAMA 1988;259:1965-1969)
Author Affiliations
From the Medical Department (Drs Woodard and Font), Health and Environment Laboratories (Mr Hearne and Drs Friedlander and Lesher), and Engineering Division (Mr Kinsey), Eastman Kodak Company, Rochester, NY. Dr Friedlander is currently with the Monsanto Company, St Louis.
Footnotes
Reprint requests to Kodak Park Medical Department, Bldg 2, First Floor, 1669 Lake Ave, Rochester, NY 14656 (Dr Woodard).
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