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Efficacy in Ovulation Induction and Corpus Luteum Support

James A. Simon, MD; Douglas R. Danforth, PhD; James S. Hutchison, PhD; Gary D. Hodgen, PhD

JAMA. 1988;259(22):3290-3295.

Abstract
The present data are the first, to our knowledge, to demonstrate the production feasibility of a commercially available medication of pure human luteinizing hormone from recombinant DNA technology (rechLH). The rechLH preparation achieved ovulation induction and corpus luteum support in the primate menstrual cycle. The observations described herein indicate the opportunity for significant improvement in the treatment of infertile women and men who require gonadal stimulation. Recombinant DNA—derived gonadotropin products, rechLH in this case, will have several therapeutic advantages compared with current medications extracted from urine. These advantages include (1) better reliability of an available supply of hormone and (2) improved treatment flexibility in determining the optimal dose ratio of follicle-stimulating hormone and luteinizing hormone or avoidance of the long-acting effects of human chorionic gonadotropin, as the needs of individual patients may dictate.

(JAMA 1988;259:3290-3295)

Author Affiliations
From The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Va (Drs Simon, Danforth, and Hodgen); and Serono Laboratories Inc, Randolph, Mass (Dr Hutchison).

Footnotes
Reprint request to The Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, 855 W Brambleton Ave, Suite B, Norfolk, VA 23510 (Dr Hodgen).

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